Sāṃkhya Kārikā verse 1

duḥkha-trayā-abhighātāt-jijñāsā tat-abhighātake hetau | dṛṣṭe sā-apārthā cet na-ekānta-atyantataḥ abhāvāt ||

duḥkha - suffering, pain, sorrowfultraya - the threeabhighāta - infliction of injury, damagejijñāsā - desire of knowing; investigation; examinationtat - that, thisabhighātaka - counteracting, removinghetu - cause, cause of; motive; reason fordṛṣṭa - seenapārthā - without any object, useless, unprofitable, worthlesscit - awareness, consciousness; to be aware of; to cause to comprehend, to observe; perceivena - no; not; nor, neitherekānta - solely, only, exclusively; absoluteness, certaintyatyanta - absolutely, completely, to the end; endless, unbroken, perpetual; permanencyabhāva - non-appearance, non-existence, absence
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Commentaries and Reflections

Commentary by TKV Desikachar:

“Sāṃkhya will not make sense to those
people who have not tried anything.
i.e. Prayer, Mantra, Medicine.”

Commentary by Paul Harvey:

“Within and around us is an absence
of certainty and permanence.”