Sāṃkhya Kārikā verse 1

duḥkha-trayā-abhighātāt-jijñāsā tat-abhighātake hetau |
dṛṣṭe sa-apārthā cet na-ekānta-atyantataḥ abhāvāt ||

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duḥkha - suffering, pain, sorrowfultraya - the threejijñāsā - desire of knowing; investigation; examinationtat - that, thishetu - causedṛṣṭa - seencit - awareness, to cause to comprehend, to observe, perceiveekānta - solely, only, exclusively; absoluteness, certaintyabhāva - non-appearance, non-existence, absence
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Commentaries and Reflections

TKV Desikachar:

“Sāṃkhya will not make sense to those people who have not tried anything.
i.e. Prayer, Mantra, Medicine.”
– TKV Desikachar Madras November 24th 1979 on Sāṃkhya and Yoga

Paul Harvey:

“Within and around us is an absence of certainty and permanence.”